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Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides To Form Nitriles
[Image: see text] A palladium(II) catalyst, in the presence of Selectfluor, enables the efficient and chemoselective transformation of primary amides into nitriles. The amides can be attached to aromatic rings, heteroaromatic rings, or aliphatic side chains, and the reactions tolerate steric bulk an...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179452/ https://www.ncbi.nlm.nih.gov/pubmed/30221526 http://dx.doi.org/10.1021/acs.orglett.8b02422 |