The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK

Upon engagement of the T cell receptor with an antigen-presenting cell, LCK initiates TCR signaling by phosphorylating its activation motifs. However, the mechanism of LCK activation specifically at the immune synapse is a major question. We show that phosphorylation of the LCK activating Y394, desp...

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Detalles Bibliográficos
Autores principales: Stephen, Louise A., ElMaghloob, Yasmin, McIlwraith, Michael J., Yelland, Tamas, Castro Sanchez, Patricia, Roda-Navarro, Pedro, Ismail, Shehab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179904/
https://www.ncbi.nlm.nih.gov/pubmed/30220567
http://dx.doi.org/10.1016/j.devcel.2018.08.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179904/
https://www.ncbi.nlm.nih.gov/pubmed/30220567
http://dx.doi.org/10.1016/j.devcel.2018.08.012

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