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The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK
Upon engagement of the T cell receptor with an antigen-presenting cell, LCK initiates TCR signaling by phosphorylating its activation motifs. However, the mechanism of LCK activation specifically at the immune synapse is a major question. We show that phosphorylation of the LCK activating Y394, desp...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179904/ https://www.ncbi.nlm.nih.gov/pubmed/30220567 http://dx.doi.org/10.1016/j.devcel.2018.08.012 |