Rare variant analysis in multiply affected families, association studies and functional analysis suggest a role for the ITGΒ4 gene in schizophrenia and bipolar disorder

Recent results imply that rare variants contribute to the risk of schizophrenia. Exome sequence data from the UK10K project was used to identify three rare, amino acid changing variants in the ITGB4 gene which segregated with schizophrenia in two families: rs750367954, rs147480547 and rs145976111. A...

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Detalles Bibliográficos
Autores principales: O'Brien, N.L., Fiorentino, A., Curtis, D., Rayner, C., Petrosellini, C., Al Eissa, M., Bass, N.J., McQuillin, A., Sharp, S.I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Publisher B. V 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179966/
https://www.ncbi.nlm.nih.gov/pubmed/29526452
http://dx.doi.org/10.1016/j.schres.2018.03.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179966/
https://www.ncbi.nlm.nih.gov/pubmed/29526452
http://dx.doi.org/10.1016/j.schres.2018.03.001

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