LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival

Epithelial dysfunction and crypt destruction are defining features of inflammatory bowel disease (IBD). However, current IBD therapies targeting epithelial dysfunction are lacking. The nuclear receptor LRH-1 (NR5A2) is expressed in intestinal epithelium and thought to contribute to epithelial renewa...

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Detalles Bibliográficos
Autores principales: Bayrer, James R., Wang, Hongtao, Nattiv, Roy, Suzawa, Miyuki, Escusa, Hazel S., Fletterick, Robert J., Klein, Ophir D., Moore, David D., Ingraham, Holly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180039/
https://www.ncbi.nlm.nih.gov/pubmed/30305617
http://dx.doi.org/10.1038/s41467-018-06137-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180039/
https://www.ncbi.nlm.nih.gov/pubmed/30305617
http://dx.doi.org/10.1038/s41467-018-06137-w

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