The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis

Ultraviolet B (UVB) radiation induces mutagenic DNA photoproducts, in particular cyclobutane pyrimidine dimers (CPDs), in epidermal keratinocytes (KC). To prevent skin carcinogenesis, these DNA photoproducts must be removed by nucleotide excision repair (NER) or apoptosis. Here we report that the UV...

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Detalles Bibliográficos
Autores principales: Pollet, Marius, Shaik, Siraz, Mescher, Melina, Frauenstein, Katrin, Tigges, Julia, Braun, Stephan A., Sondenheimer, Kevin, Kaveh, Mana, Bruhs, Anika, Meller, Stephan, Homey, Bernhard, Schwarz, Agatha, Esser, Charlotte, Douki, Thierry, Vogel, Christoph F. A., Krutmann, Jean, Haarmann-Stemmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180092/
https://www.ncbi.nlm.nih.gov/pubmed/30013037
http://dx.doi.org/10.1038/s41418-018-0160-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180092/
https://www.ncbi.nlm.nih.gov/pubmed/30013037
http://dx.doi.org/10.1038/s41418-018-0160-1

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