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Increasing G9a automethylation sensitizes B acute lymphoblastic leukemia cells to glucocorticoid-induced death
Synthetic glucocorticoids (GCs) are used to treat lymphoid cancers, but many patients develop resistance to treatment, especially to GC. By identifying genes that influence sensitivity to GC-induced cell death, we found that histone methyltransferases G9a and G9a-like protein (GLP), two glucocortico...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180122/ https://www.ncbi.nlm.nih.gov/pubmed/30305606 http://dx.doi.org/10.1038/s41419-018-1110-z |