A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases

Homeostatic regulation of G-quadruplexes (G4s), four-stranded structures that can form in guanine-rich nucleic acids, requires G4 unwinding helicases. The mechanisms that mediate G4 unwinding remain unknown. We report the structure of a bacterial RecQ DNA helicase bound to resolved G4 DNA. Unexpecte...

Descripción completa

Detalles Bibliográficos
Autores principales: Voter, Andrew F., Qiu, Yupeng, Tippana, Ramreddy, Myong, Sua, Keck, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180126/
https://www.ncbi.nlm.nih.gov/pubmed/30305632
http://dx.doi.org/10.1038/s41467-018-06751-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180126/
https://www.ncbi.nlm.nih.gov/pubmed/30305632
http://dx.doi.org/10.1038/s41467-018-06751-8

Ejemplares similares