Shank2 Mutant Mice Display Hyperactivity Insensitive to Methylphenidate and Reduced Flexibility in Social Motivation, but Normal Social Recognition

Mouse models of autism can be used to study evolutionarily conserved mechanisms underlying behavioral abnormalities in social communication and repetitive behaviors. SHANK genes code for synaptic scaffolding proteins at excitatory synapses and mutations in all SHANK genes have been associated with a...

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Detalles Bibliográficos
Autores principales: Ey, Elodie, Torquet, Nicolas, de Chaumont, Fabrice, Lévi-Strauss, Julie, Ferhat, Allain-Thibeault, Le Sourd, Anne-Marie, Boeckers, Tobias M., Bourgeron, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180161/
https://www.ncbi.nlm.nih.gov/pubmed/30337855
http://dx.doi.org/10.3389/fnmol.2018.00365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180161/
https://www.ncbi.nlm.nih.gov/pubmed/30337855
http://dx.doi.org/10.3389/fnmol.2018.00365

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