Diphthamide affects selenoprotein expression: Diphthamide deficiency reduces selenocysteine incorporation, decreases selenite sensitivity and pre-disposes to oxidative stress

The diphthamide modification of translation elongation factor 2 is highly conserved in eukaryotes and archaebacteria. Nevertheless, cells lacking diphthamide can carry out protein synthesis and are viable. We have analyzed the phenotypes of diphthamide deficient cells and found that diphthamide defi...

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Detalles Bibliográficos
Autores principales: Mayer, Klaus, Mundigl, Olaf, Kettenberger, Hubert, Birzele, Fabian, Stahl, Sebastian, Pastan, Ira, Brinkmann, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180344/
https://www.ncbi.nlm.nih.gov/pubmed/30312900
http://dx.doi.org/10.1016/j.redox.2018.09.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180344/
https://www.ncbi.nlm.nih.gov/pubmed/30312900
http://dx.doi.org/10.1016/j.redox.2018.09.015

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