Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans

Aging is accompanied by a pervasive collapse of proteostasis, while reducing general protein synthesis promotes longevity across taxa. Here, we show that the eIF4E isoform IFE-2 is increasingly sequestered in mRNA processing (P) bodies during aging and upon stress in Caenorhabditis elegans. Loss of...

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Detalles Bibliográficos
Autores principales: Rieckher, Matthias, Markaki, Maria, Princz, Andrea, Schumacher, Björn, Tavernarakis, Nektarios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180348/
https://www.ncbi.nlm.nih.gov/pubmed/30282029
http://dx.doi.org/10.1016/j.celrep.2018.09.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180348/
https://www.ncbi.nlm.nih.gov/pubmed/30282029
http://dx.doi.org/10.1016/j.celrep.2018.09.009

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