Sphingosine 1-phosphate receptor subtype 3 (S1P(3)) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization

BACKGROUND: The pathogenic roles of receptor-mediated sphingosine 1-phosphate (S1P) signaling in cerebral ischemia have been evidenced mainly through the efficacy of FTY720 that binds non-selectively to four of the five S1P receptors (S1P(1,3,4,5)). Recently, S1P(1) and S1P(2) were identified as spe...

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Detalles Bibliográficos
Autores principales: Gaire, Bhakta Prasad, Song, Mi-Ryoung, Choi, Ji Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180378/
https://www.ncbi.nlm.nih.gov/pubmed/30305119
http://dx.doi.org/10.1186/s12974-018-1323-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180378/
https://www.ncbi.nlm.nih.gov/pubmed/30305119
http://dx.doi.org/10.1186/s12974-018-1323-1

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