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Sphingosine 1-phosphate receptor subtype 3 (S1P(3)) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization
BACKGROUND: The pathogenic roles of receptor-mediated sphingosine 1-phosphate (S1P) signaling in cerebral ischemia have been evidenced mainly through the efficacy of FTY720 that binds non-selectively to four of the five S1P receptors (S1P(1,3,4,5)). Recently, S1P(1) and S1P(2) were identified as spe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180378/ https://www.ncbi.nlm.nih.gov/pubmed/30305119 http://dx.doi.org/10.1186/s12974-018-1323-1 |