Retinal Detachment-Induced Müller Glial Cell Swelling Activates TRPV4 Ion Channels and Triggers Photoreceptor Death at Body Temperature

Using region-specific injection of hyaluronic acid, we developed a mouse model of acute retinal detachment (RD) to investigate molecular mechanisms of photoreceptor cell death triggered by RD. We focused on the transient receptor potential vanilloid 4 (TRPV4) ion channel, which functions as a thermo...

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Detalles Bibliográficos
Autores principales: Matsumoto, Hidetaka, Sugio, Shouta, Seghers, François, Krizaj, David, Akiyama, Hideo, Ishizaki, Yasuki, Gailly, Philippe, Shibasaki, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181316/
https://www.ncbi.nlm.nih.gov/pubmed/30143574
http://dx.doi.org/10.1523/JNEUROSCI.0897-18.2018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181316/
https://www.ncbi.nlm.nih.gov/pubmed/30143574
http://dx.doi.org/10.1523/JNEUROSCI.0897-18.2018

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