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Heme oxygenase-1 inducer and carbon monoxide–releasing molecule enhance the effects of gabapentinoids by modulating glial activation during neuropathic pain in mice

INTRODUCTION: Neuropathic pain is one of the most difficult-to-treat symptoms. Although gabapentinoids are classified as first-line drugs, they have only modest efficacy. OBJECTIVES: The aim of this study was to investigate whether treatment with the heme oxygenase-1 (HO-1) inducer cobalt protoporph...

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Detalles Bibliográficos
Autores principales: Godai, Kohei, Kanmura, Yuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181470/
https://www.ncbi.nlm.nih.gov/pubmed/30534628
http://dx.doi.org/10.1097/PR9.0000000000000677