Cargando…
2.0 Å resolution crystal structure of human polκ reveals a new catalytic function of N-clasp in DNA replication
Human polymerase kappa (polκ) is a distinct Y-family DNA polymerase with a unique N-terminal N-clasp domain. The N-clasp renders polκ’s high efficiency and accuracy in DNA replication and lesion bypass. How N-clasp empowers polκ in replication remains unclear due to the disordering of N-clasp. Here,...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181923/ https://www.ncbi.nlm.nih.gov/pubmed/30310122 http://dx.doi.org/10.1038/s41598-018-33371-5 |