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High fidelity CRISPR/Cas9 increases precise monoallelic and biallelic editing events in primordial germ cells
Primordial germ cells (PGCs), the embryonic precursors of the sperm and egg, are used for the introduction of genetic modifications into avian genome. Introduction of small defined sequences using genome editing has not been demonstrated in bird species. Here, we compared oligonucleotide-mediated HD...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181960/ https://www.ncbi.nlm.nih.gov/pubmed/30310080 http://dx.doi.org/10.1038/s41598-018-33244-x |