Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission

A 29 nucleotide deletion in open reading frame 8 (ORF8) is the most obvious genetic change in severe acute respiratory syndrome coronavirus (SARS-CoV) during its emergence in humans. In spite of intense study, it remains unclear whether the deletion actually reflects adaptation to humans. Here we en...

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Detalles Bibliográficos
Autores principales: Muth, Doreen, Corman, Victor Max, Roth, Hanna, Binger, Tabea, Dijkman, Ronald, Gottula, Lina Theresa, Gloza-Rausch, Florian, Balboni, Andrea, Battilani, Mara, Rihtarič, Danijela, Toplak, Ivan, Ameneiros, Ramón Seage, Pfeifer, Alexander, Thiel, Volker, Drexler, Jan Felix, Müller, Marcel Alexander, Drosten, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181990/
https://www.ncbi.nlm.nih.gov/pubmed/30310104
http://dx.doi.org/10.1038/s41598-018-33487-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181990/
https://www.ncbi.nlm.nih.gov/pubmed/30310104
http://dx.doi.org/10.1038/s41598-018-33487-8

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