Increased levels of RECQ5 shift DNA repair from canonical to alternative pathways

RECQ5 (RECQL5) is one of several human helicases that dissociates RAD51–DNA filaments. The gene that encodes RECQ5 is frequently amplified in human tumors, but it is not known whether amplification correlates with increased gene expression, or how increased RECQ5 levels affect DNA repair at nicks an...

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Detalles Bibliográficos
Autores principales: Olson, Henry C, Davis, Luther, Kiianitsa, Kostantin, Khoo, Kevin J, Liu, Yilun, Knijnenburg, Theo A, Maizels, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182128/
https://www.ncbi.nlm.nih.gov/pubmed/30107528
http://dx.doi.org/10.1093/nar/gky727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182128/
https://www.ncbi.nlm.nih.gov/pubmed/30107528
http://dx.doi.org/10.1093/nar/gky727

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