SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability

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Mutations in SPOP, the gene most frequently point-mutated in primary prostate cancer, are associated with a high degree of genomic instability and deficiency in homologous recombination repair of DNA but the underlying mechanisms behind this defect are currently unknown. Here we demonstrate that SPO...

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Detalles Bibliográficos
Autores principales: Hjorth-Jensen, Kim, Maya-Mendoza, Apolinar, Dalgaard, Nanna, Sigurðsson, Jón O, Bartek, Jiri, Iglesias-Gato, Diego, Olsen, Jesper V, Flores-Morales, Amilcar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182143/
https://www.ncbi.nlm.nih.gov/pubmed/30124983
http://dx.doi.org/10.1093/nar/gky719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182143/
https://www.ncbi.nlm.nih.gov/pubmed/30124983
http://dx.doi.org/10.1093/nar/gky719

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