Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2

Maintenance of topological homeostasis is vital for gene expression and genome replication in all organisms. Similar to other circular genomes, also mitochondrial DNA (mtDNA) is known to exist in various different topological forms, although their functional significance remains unknown. We report h...

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Detalles Bibliográficos
Autores principales: Hangas, Anu, Aasumets, Koit, Kekäläinen, Nina J, Paloheinä, Mika, Pohjoismäki, Jaakko L, Gerhold, Joachim M, Goffart, Steffi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182158/
https://www.ncbi.nlm.nih.gov/pubmed/30169847
http://dx.doi.org/10.1093/nar/gky793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182158/
https://www.ncbi.nlm.nih.gov/pubmed/30169847
http://dx.doi.org/10.1093/nar/gky793

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