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Population Pharmacokinetics and Exposure-Response Relationships of Naldemedine

PURPOSE: To characterize population pharmacokinetic (PK) of naldemedine, to identify factors which influence naldemedine PK, and to evaluate their clinical relevancy based on exposure-response relationships. METHODS: A population PK model was developed with pooled naldemedine concentrations from hea...

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Detalles Bibliográficos
Autores principales:	Kubota, Ryuji, Fukumura, Kazuya, Wajima, Toshihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182381/ https://www.ncbi.nlm.nih.gov/pubmed/30280262 http://dx.doi.org/10.1007/s11095-018-2501-7

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