Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above

The instability of DNA triplexes particularly at neutral pH and above severely limits their applications. Here, we demonstrate that the introduction of a thiazole orange (TO) intercalator onto a thymine nucleobase in triplex forming oligonucleotides (TFOs) resolves this problem. The stabilising effe...

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Detalles Bibliográficos
Autores principales: Walsh, Sarah, El-Sagheer, Afaf Helmy, Brown, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182420/
https://www.ncbi.nlm.nih.gov/pubmed/30393529
http://dx.doi.org/10.1039/c8sc02418a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182420/
https://www.ncbi.nlm.nih.gov/pubmed/30393529
http://dx.doi.org/10.1039/c8sc02418a

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