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Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above
The instability of DNA triplexes particularly at neutral pH and above severely limits their applications. Here, we demonstrate that the introduction of a thiazole orange (TO) intercalator onto a thymine nucleobase in triplex forming oligonucleotides (TFOs) resolves this problem. The stabilising effe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182420/ https://www.ncbi.nlm.nih.gov/pubmed/30393529 http://dx.doi.org/10.1039/c8sc02418a |