Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells

We engineered the first chimeric, bispecific lectin, with two rationally oriented and distinct recognition surfaces. This lectin, coined Janus lectin in allusion to the two-faced roman god, is able to bind independently to both fucosylated and sialylated glycoconjugates. The multivalent presentation...

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Detalles Bibliográficos
Autores principales: Ribeiro, João P., Villringer, Sarah, Goyard, David, Coche-Guerente, Liliane, Höferlin, Manuela, Renaudet, Olivier, Römer, Winfried, Imberty, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182566/
https://www.ncbi.nlm.nih.gov/pubmed/30393524
http://dx.doi.org/10.1039/c8sc02730g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182566/
https://www.ncbi.nlm.nih.gov/pubmed/30393524
http://dx.doi.org/10.1039/c8sc02730g

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