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Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells
We engineered the first chimeric, bispecific lectin, with two rationally oriented and distinct recognition surfaces. This lectin, coined Janus lectin in allusion to the two-faced roman god, is able to bind independently to both fucosylated and sialylated glycoconjugates. The multivalent presentation...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182566/ https://www.ncbi.nlm.nih.gov/pubmed/30393524 http://dx.doi.org/10.1039/c8sc02730g |