Haplotype analysis suggest that the MLH1 c.2059C > T mutation is a Swedish founder mutation

Lynch syndrome (LS) predisposes to a spectrum of cancers and increases the lifetime risk of developing colorectal- or endometrial cancer to over 50%. Lynch syndrome is dominantly inherited and is caused by defects in DNA mismatch-repair genes MLH1, MSH2, MSH6 or PMS2, with the vast majority detected...

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Detalles Bibliográficos
Autores principales: von Salomé, Jenny, Liu, Tao, Keihäs, Markku, Morak, Moni, Holinski-Feder, Elke, Berry, Ian R., Moilanen, Jukka S., Baert-Desurmont, Stéphanie, Lindblom, Annika, Lagerstedt-Robinson, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182575/
https://www.ncbi.nlm.nih.gov/pubmed/29288294
http://dx.doi.org/10.1007/s10689-017-0067-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182575/
https://www.ncbi.nlm.nih.gov/pubmed/29288294
http://dx.doi.org/10.1007/s10689-017-0067-x

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