Cargando…

Innate immune activity as a predictor of persistent insulin secretion and association with responsiveness to CTLA4-Ig treatment in recent-onset type 1 diabetes

AIMS/HYPOTHESIS: The study aimed to determine whether discrete subtypes of type 1 diabetes exist, based on immunoregulatory profiles at clinical onset, as this has significant implications for disease treatment and prevention as well as the design and analysis of clinical trials. METHODS: Using a pl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cabrera, Susanne M., Engle, Samuel, Kaldunski, Mary, Jia, Shuang, Geoffrey, Rhonda, Simpson, Pippa, Szabo, Aniko, Speake, Cate, Greenbaum, Carla J., Chen, Yi-Guang, Hessner, Martin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182660/ https://www.ncbi.nlm.nih.gov/pubmed/30167736 http://dx.doi.org/10.1007/s00125-018-4708-x

Ejemplares similares

Molecular Signatures Differentiate Immune States in Type 1 Diabetic Families
por: Chen, Yi-Guang, et al.
Publicado: (2014)

Modulation of the diet and gastrointestinal microbiota normalizes systemic inflammation and β-cell chemokine expression associated with autoimmune diabetes susceptibility
por: Henschel, Angela M., et al.
Publicado: (2018)

Identification of a Serum-Induced Transcriptional Signature Associated With Type 1 Diabetes in the BioBreeding Rat
por: Kaldunski, Mary, et al.
Publicado: (2010)

Temporal induction of immunoregulatory processes coincides with age-dependent resistance to viral-induced Type 1 Diabetes
por: Chen, Yi-Guang, et al.
Publicado: (2013)

Characterizing T cell responses to enzymatically modified beta cell neo-epitopes
por: Nguyen, Hai, et al.
Publicado: (2023)

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes
por: Sims, Emily K., et al.
Publicado: (2019)

THU274 Gluten Free Diet Reduces Systemic Innate Inflammation in Children Genetically Susceptible To Type 1 Diabetes
por: Coren, Alison T, et al.
Publicado: (2023)

Effects of CTLA4-Ig on human monocytes
por: Tono, Toshihiro, et al.
Publicado: (2017)

Intermittent neonatal hypoxia elicits the upregulation of inflammatory‐related genes in adult male rats through long‐lasting programming effects
por: Gehrand, Ashley L., et al.
Publicado: (2015)

Response to Comment on So et al. Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody–Positive Individuals. Diabetes Care 2020;43:913–917
por: So, Michelle, et al.
Publicado: (2020)

A standardized metric to enhance clinical trial design and outcome interpretation in type 1 diabetes
por: Ylescupidez, Alyssa, et al.
Publicado: (2023)

Functional Characterization of Human T Cell Hyporesponsiveness Induced by CTLA4-Ig
por: Rochman, Yrina, et al.
Publicado: (2015)

CTLA4-Ig treatment prevents murine experimental autoimmune encephalomyelitis
por: Cross, A.H., et al.
Publicado: (1994)

CTLA-4Ig Improves Hyperalgesia in a Mouse Model of Osteoporosis
por: Nagao, Nobuto, et al.
Publicado: (2020)

Investigation of coordination and order in transcription regulation of innate and adaptive immunity genes in type 1 diabetes
por: Gao, Shouguo, et al.
Publicado: (2017)

RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4
por: Sekiya, Takashi, et al.
Publicado: (2019)

Probiotic normalization of systemic inflammation in siblings of type 1 diabetes patients: an open-label pilot study
por: Cabrera, Susanne M., et al.
Publicado: (2022)

Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258–264
por: Sims, Emily K., et al.
Publicado: (2019)

CTLA4-Ig immunosuppressive activity at the level of dendritic cell/T cell crosstalk
por: Mayer, Edda, et al.
Publicado: (2013)

Broadening Our Understanding Type 1 Diabetes Heterogeneity by Exploring Effects of Race/Ethnicity on Disease Trajectory
por: Hessner, Martin J, et al.
Publicado: (2020)

Evaluation of Candidate Biomarkers of Type 1 Diabetes via the Core for Assay Validation
por: Speake, Cate, et al.
Publicado: (2015)

Blood PD-1(+)TFh and CTLA-4(+)CD4(+) T cells predict remission after CTLA-4Ig treatment in early rheumatoid arthritis
por: Aldridge, Jonathan, et al.
Publicado: (2021)

A Novel Therapeutic Effect of a New Variant of CTLA4-Ig with Four Antennas That Are Terminally Capped with Sialic Acid in the CTLA4 Region
por: Piao, Yongwei, et al.
Publicado: (2022)

Constitutive Clathrin-mediated Endocytosis of CTLA-4 Persists during T Cell Activation
por: Qureshi, Omar S., et al.
Publicado: (2012)

Functional Characteristics of C-terminal Lysine to Cysteine Mutant Form of CTLA-4Ig
por: Kim, Bongi, et al.
Publicado: (2013)

Successful Treatment of T Cell-Mediated Acute Rejection with Delayed CTLA4-Ig in Mice
por: Young, James S., et al.
Publicado: (2017)

The Relationship of Immune Cell Signatures to Patient Survival Varies within and between Tumor Types
por: Linsley, Peter S., et al.
Publicado: (2015)

Repeated Exposure to Severely Limited Sleep Results in Distinctive and Persistent Physiological Imbalances in Rats
por: Everson, Carol A., et al.
Publicado: (2011)

Persistent intrathecal secretion of oligoclonal, Borrelia burgdorferi-specific IgG in chronic meningoradiculomyelitis
por: Martin, R., et al.
Publicado: (1988)

TGF-β2 mediated secretion of sCTLA-4 from regulatory T cells
por: Khanolkar, R, et al.
Publicado: (2015)

Malaria sporozoite proteome leaves a trail
por: Vignali, Marissa, et al.
Publicado: (2009)

Development of an intravital imaging system for the synovial tissue reveals the dynamics of CTLA-4 Ig in vivo
por: Hasegawa, Tetsuo, et al.
Publicado: (2020)

Effect of CTLA4-Ig on Obliterative Bronchiolitis in a Mouse Intrapulmonary Tracheal Transplantation Model
por: Suzuki, Yamato, et al.
Publicado: (2021)

Targeting inflammation and immune activation to improve CTLA4-Ig-based modulation of transplant rejection
por: Iglesias, Marcos, et al.
Publicado: (2022)

Cloning and identification of the CTLA-4IgV gene and functional application of vaccine in Xinjiang sheep
por: Kong, Huifang, et al.
Publicado: (2022)

Brief Communication on Pathologic Assessment of Persistent Stable Metastatic Lesions in Patients Treated With Anti-CTLA-4 or Anti-CTLA-4 + Anti-PD-1 Therapy
por: Buchbinder, Elizabeth I., et al.
Publicado: (2023)

Identification of a Novel Gene for Diabetic Traits in Rats, Mice, and Humans
por: Tsaih, Shirng-Wern, et al.
Publicado: (2014)

Probiotic Supplementation with Lactobacillus plantarum 299v Lowers Systemic Inflammation, Reduces Islet ER Stress and Prevents Type 1 Diabetes in BioBreeding Rats
por: Sargin, Pinar, et al.
Publicado: (2021)

Copy Number Loss of the Interferon Gene Cluster in Melanomas Is Linked to Reduced T Cell Infiltrate and Poor Patient Prognosis
por: Linsley, Peter S., et al.
Publicado: (2014)

The many faces of islet antigen‐specific CD8 T cells: clues to clinical outcome in type 1 diabetes
por: Wiedeman, Alice E, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_uvct2j1eas0gv3tm2vqr8u820r