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Recent advances in understanding non-celiac gluten sensitivity
Non-celiac gluten sensitivity (NCGS) is a condition characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing foods in the absence of celiac disease and wheat allergy. The diagnosis is cumbersome and currently confirmed only by gluten withdrawal and doub...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182669/ https://www.ncbi.nlm.nih.gov/pubmed/30363819 http://dx.doi.org/10.12688/f1000research.15849.1 |
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author | Barbaro, Maria Raffaella Cremon, Cesare Stanghellini, Vincenzo Barbara, Giovanni |
author_facet | Barbaro, Maria Raffaella Cremon, Cesare Stanghellini, Vincenzo Barbara, Giovanni |
author_sort | Barbaro, Maria Raffaella |
collection | PubMed |
description | Non-celiac gluten sensitivity (NCGS) is a condition characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing foods in the absence of celiac disease and wheat allergy. The diagnosis is cumbersome and currently confirmed only by gluten withdrawal and double-blind placebo challenge protocols. There is great overlap in symptoms between NCGS and other functional gastrointestinal disorders, making a differential diagnosis difficult. The pathophysiology of NCGS is largely unclear, and there are contrasting data on the trigger of this condition. This review will highlight the state-of-the-art knowledge on NCGS and the key open questions. |
format | Online Article Text |
id | pubmed-6182669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-61826692018-10-23 Recent advances in understanding non-celiac gluten sensitivity Barbaro, Maria Raffaella Cremon, Cesare Stanghellini, Vincenzo Barbara, Giovanni F1000Res Review Non-celiac gluten sensitivity (NCGS) is a condition characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing foods in the absence of celiac disease and wheat allergy. The diagnosis is cumbersome and currently confirmed only by gluten withdrawal and double-blind placebo challenge protocols. There is great overlap in symptoms between NCGS and other functional gastrointestinal disorders, making a differential diagnosis difficult. The pathophysiology of NCGS is largely unclear, and there are contrasting data on the trigger of this condition. This review will highlight the state-of-the-art knowledge on NCGS and the key open questions. F1000 Research Limited 2018-10-11 /pmc/articles/PMC6182669/ /pubmed/30363819 http://dx.doi.org/10.12688/f1000research.15849.1 Text en Copyright: © 2018 Barbaro MR et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Barbaro, Maria Raffaella Cremon, Cesare Stanghellini, Vincenzo Barbara, Giovanni Recent advances in understanding non-celiac gluten sensitivity |
title | Recent advances in understanding non-celiac gluten sensitivity |
title_full | Recent advances in understanding non-celiac gluten sensitivity |
title_fullStr | Recent advances in understanding non-celiac gluten sensitivity |
title_full_unstemmed | Recent advances in understanding non-celiac gluten sensitivity |
title_short | Recent advances in understanding non-celiac gluten sensitivity |
title_sort | recent advances in understanding non-celiac gluten sensitivity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182669/ https://www.ncbi.nlm.nih.gov/pubmed/30363819 http://dx.doi.org/10.12688/f1000research.15849.1 |
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