Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale

L-praziquantel (PZQ) pharmacokinetic data were analyzed from two relative bioavailability Phase 1 studies in adult, healthy subjects with two new oral dispersion tablet (ODT) formulations of L-PZQ administered under various combinations of co-administration with food, water, and/or crushing. Linear...

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Detalles Bibliográficos
Autores principales: Bonate, Peter L., Wang, Tianli, Passier, Paul, Bagchus, Wilhelmina, Burt, Howard, Lüpfert, Christian, Abla, Nada, Kovac, Jana, Keiser, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182730/
https://www.ncbi.nlm.nih.gov/pubmed/30218416
http://dx.doi.org/10.1007/s10928-018-9601-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182730/
https://www.ncbi.nlm.nih.gov/pubmed/30218416
http://dx.doi.org/10.1007/s10928-018-9601-1

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