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siAbasic: a comprehensive database for potent siRNA-6Ø sequences without off-target effects
Small interfering RNA (siRNA) is widely used to specifically silence target gene expression, but its microRNA (miRNA)-like function inevitably suppresses hundreds of off-targets. Recently, complete elimination of the off-target repression has been achieved by introducing an abasic nucleotide to the...
Autores principales: | Park, Jongyeun, Ahn, Seung Hyun, Cho, Kwang Moon, Gu, Dowoon, Jang, Eun-Sook, Chi, Sung Wook |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6183071/ https://www.ncbi.nlm.nih.gov/pubmed/30321353 http://dx.doi.org/10.1093/database/bay109 |
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