ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines

Dysfunction of the noradrenergic (NE) neurons is implicated in the pathogenesis of bipolar disorder (BPD). ErbB4 is highly expressed in NE neurons, and its genetic variation has been linked to BPD; however, how ErbB4 regulates NE neuronal function and contributes to BPD pathogenesis is unclear. Here...

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Detalles Bibliográficos
Autores principales: Cao, Shu-Xia, Zhang, Ying, Hu, Xing-Yue, Hong, Bin, Sun, Peng, He, Hai-Yang, Geng, Hong-Yan, Bao, Ai-Min, Duan, Shu-Min, Yang, Jian-Ming, Gao, Tian-Ming, Lian, Hong, Li, Xiao-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185106/
https://www.ncbi.nlm.nih.gov/pubmed/30179154
http://dx.doi.org/10.7554/eLife.39907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185106/
https://www.ncbi.nlm.nih.gov/pubmed/30179154
http://dx.doi.org/10.7554/eLife.39907

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