Cancer-Associated PIK3CA Mutations in Overgrowth Disorders

PIK3CA is one of the most commonly mutated genes in solid cancers. PIK3CA mutations are also found in benign overgrowth syndromes, collectively known as PIK3CA-related overgrowth spectrum (PROS). As in cancer, PIK3CA mutations in PROS arise postzygotically, but unlike in cancer, these mutations aris...

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Detalles Bibliográficos
Autores principales: Madsen, Ralitsa R., Vanhaesebroeck, Bart, Semple, Robert K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185869/
https://www.ncbi.nlm.nih.gov/pubmed/30197175
http://dx.doi.org/10.1016/j.molmed.2018.08.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185869/
https://www.ncbi.nlm.nih.gov/pubmed/30197175
http://dx.doi.org/10.1016/j.molmed.2018.08.003

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