Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion

HIV-1 Env, a trimer of gp120-gp41 heterodimers, mediates membrane fusion after binding host receptor CD4. Receptor binding displaces V1V2 loops from Env's apex, allowing coreceptor binding and opening Env to enable gp41-mediated fusion. We present 3.54 Å and 4.06 Å cryoelectron microscopy struc...

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Detalles Bibliográficos
Autores principales: Wang, Haoqing, Barnes, Christopher O., Yang, Zhi, Nussenzweig, Michel C., Bjorkman, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185872/
https://www.ncbi.nlm.nih.gov/pubmed/30308160
http://dx.doi.org/10.1016/j.chom.2018.09.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185872/
https://www.ncbi.nlm.nih.gov/pubmed/30308160
http://dx.doi.org/10.1016/j.chom.2018.09.003

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