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REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis
The roles of Rev-erbα and circadian clock in colonic inflammation remain unclarified. Here we show colon clock genes (including Rev-erbα) are dysregulated in mice with DSS-induced colitis. In turn, disruption of the circadian clock exacerbates experimental colitis. Rev-erbα-deficient mice are more s...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185905/ https://www.ncbi.nlm.nih.gov/pubmed/30315268 http://dx.doi.org/10.1038/s41467-018-06568-5 |