Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions

The turnover of brain proteins is critical for organism survival, and its perturbations are linked to pathology. Nevertheless, protein lifetimes have been difficult to obtain in vivo. They are readily measured in vitro by feeding cells with isotopically labeled amino acids, followed by mass spectrom...

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Detalles Bibliográficos
Autores principales: Fornasiero, Eugenio F., Mandad, Sunit, Wildhagen, Hanna, Alevra, Mihai, Rammner, Burkhard, Keihani, Sarva, Opazo, Felipe, Urban, Inga, Ischebeck, Till, Sakib, M. Sadman, Fard, Maryam K., Kirli, Koray, Centeno, Tonatiuh Pena, Vidal, Ramon O., Rahman, Raza-Ur, Benito, Eva, Fischer, André, Dennerlein, Sven, Rehling, Peter, Feussner, Ivo, Bonn, Stefan, Simons, Mikael, Urlaub, Henning, Rizzoli, Silvio O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185916/
https://www.ncbi.nlm.nih.gov/pubmed/30315172
http://dx.doi.org/10.1038/s41467-018-06519-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185916/
https://www.ncbi.nlm.nih.gov/pubmed/30315172
http://dx.doi.org/10.1038/s41467-018-06519-0

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