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Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions
The turnover of brain proteins is critical for organism survival, and its perturbations are linked to pathology. Nevertheless, protein lifetimes have been difficult to obtain in vivo. They are readily measured in vitro by feeding cells with isotopically labeled amino acids, followed by mass spectrom...
Autores principales: | Fornasiero, Eugenio F., Mandad, Sunit, Wildhagen, Hanna, Alevra, Mihai, Rammner, Burkhard, Keihani, Sarva, Opazo, Felipe, Urban, Inga, Ischebeck, Till, Sakib, M. Sadman, Fard, Maryam K., Kirli, Koray, Centeno, Tonatiuh Pena, Vidal, Ramon O., Rahman, Raza-Ur, Benito, Eva, Fischer, André, Dennerlein, Sven, Rehling, Peter, Feussner, Ivo, Bonn, Stefan, Simons, Mikael, Urlaub, Henning, Rizzoli, Silvio O. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185916/ https://www.ncbi.nlm.nih.gov/pubmed/30315172 http://dx.doi.org/10.1038/s41467-018-06519-0 |
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