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Probing aggrephagy using chemically-induced protein aggregates

Selective types of autophagy mediate the clearance of specific cellular components and are essential to maintain cellular homeostasis. However, tools to directly induce and monitor such pathways are limited. Here we introduce the PIM (particles induced by multimerization) assay as a tool for the stu...

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Detalles Bibliográficos
Autores principales: Janssen, Anne F. J., Katrukha, Eugene A., van Straaten, Wendy, Verlhac, Pauline, Reggiori, Fulvio, Kapitein, Lukas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185936/
https://www.ncbi.nlm.nih.gov/pubmed/30315152
http://dx.doi.org/10.1038/s41467-018-06674-4