EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription

Inv(3q26) and t(3:3)(q21;q26) are specific to poor-prognosis myeloid malignancies, and result in marked overexpression of EVI1, a zinc-finger transcription factor and myeloid-specific oncoprotein. Despite extensive study, the mechanism by which EVI1 contributes to myeloid malignancy remains unclear....

Descripción completa

Detalles Bibliográficos
Autores principales: Ayoub, Edward, Wilson, Michael P., McGrath, Kathleen E., Li, Allison J., Frisch, Benjamin J., Palis, James, Calvi, Laura M., Zhang, Yi, Perkins, Archibald S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185954/
https://www.ncbi.nlm.nih.gov/pubmed/30315161
http://dx.doi.org/10.1038/s41467-018-06208-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185954/
https://www.ncbi.nlm.nih.gov/pubmed/30315161
http://dx.doi.org/10.1038/s41467-018-06208-y

Ejemplares similares