DUSP10 constrains innate IL-33-mediated cytokine production in ST2(hi) memory-type pathogenic Th2 cells

ST2(hi) memory-type Th2 cells are identified as a pathogenic subpopulation in eosinophilic airway inflammation. These ST2(hi) pathogenic Th2 cells produce large amount of IL-5 upon T cell receptor stimulation, but not in response to IL-33 treatment. By contrast, IL-33 alone induces cytokine producti...

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Detalles Bibliográficos
Autores principales: Yamamoto, Takeshi, Endo, Yusuke, Onodera, Atsushi, Hirahara, Kiyoshi, Asou, Hikari K., Nakajima, Takahiro, Kanno, Toshio, Ouchi, Yasuo, Uematsu, Satoshi, Nishimasu, Hiroshi, Nureki, Osamu, Tumes, Damon J., Shimojo, Naoki, Nakayama, Toshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185962/
https://www.ncbi.nlm.nih.gov/pubmed/30315197
http://dx.doi.org/10.1038/s41467-018-06468-8

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