Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age

This report demonstrates insoluble alpha-synuclein (aSYN)+ aggregates in human sporadic Parkinson’s disease (PD) midbrain that are linearly correlated with loss of glucocerebrosidase (GCase) activity. To identify early protein-lipid interactions that coincide with loss of lipid homeostasis, an aging...

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Detalles Bibliográficos
Autores principales: Brekk, Oeystein R., Moskites, Alyssa, Isacson, Ole, Hallett, Penelope J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185981/
https://www.ncbi.nlm.nih.gov/pubmed/30315256
http://dx.doi.org/10.1038/s41598-018-33474-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185981/
https://www.ncbi.nlm.nih.gov/pubmed/30315256
http://dx.doi.org/10.1038/s41598-018-33474-z

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