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Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age

This report demonstrates insoluble alpha-synuclein (aSYN)+ aggregates in human sporadic Parkinson’s disease (PD) midbrain that are linearly correlated with loss of glucocerebrosidase (GCase) activity. To identify early protein-lipid interactions that coincide with loss of lipid homeostasis, an aging...

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Detalles Bibliográficos
Autores principales:	Brekk, Oeystein R., Moskites, Alyssa, Isacson, Ole, Hallett, Penelope J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185981/ https://www.ncbi.nlm.nih.gov/pubmed/30315256 http://dx.doi.org/10.1038/s41598-018-33474-z

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