Humanization of the Blood–Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus — Lessons from Three Unsuccessful Approaches

ATP-binding cassette (ABC) transporters are of major importance for the restricted access of toxins and drugs to the human body. At the body's barrier tissues like the blood–brain barrier, these transporters are highly represented. Especially, ABCB1 (P-glycoprotein) has been a priority target o...

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Detalles Bibliográficos
Autores principales: Krohn, Markus, Wanek, Thomas, Menet, Marie-Claude, Noack, Andreas, Declèves, Xavier, Langer, Oliver, Löscher, Wolfgang, Pahnke, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Akadémiai Kiadó 2018
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186017/
https://www.ncbi.nlm.nih.gov/pubmed/30345087
http://dx.doi.org/10.1556/1886.2018.00008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186017/
https://www.ncbi.nlm.nih.gov/pubmed/30345087
http://dx.doi.org/10.1556/1886.2018.00008

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