Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8(+) T cells in the tumor microenvironment

BACKGROUND: Several studies have established a correlation between the VEGF–VEGFR2 axis and an immunosuppressive microenvironment; this immunosuppression can be overcome by anti-angiogenic reagents, such as ramucirumab (RAM). However, little is known about the immunological impact of anti-angiogenic...

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Detalles Bibliográficos
Autores principales: Tada, Yasuko, Togashi, Yosuke, Kotani, Daisuke, Kuwata, Takeshi, Sato, Eichi, Kawazoe, Akihito, Doi, Toshihiko, Wada, Hisashi, Nishikawa, Hiroyoshi, Shitara, Kohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186121/
https://www.ncbi.nlm.nih.gov/pubmed/30314524
http://dx.doi.org/10.1186/s40425-018-0403-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186121/
https://www.ncbi.nlm.nih.gov/pubmed/30314524
http://dx.doi.org/10.1186/s40425-018-0403-1

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