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Presynaptic GCaMP expression decreases vesicle release probability at the calyx of Held

Synaptic vesicle (SV) exocytosis is intimately dependent on free local Ca(2+) near active zones. Genetically encoded calcium indicators (GECIs) have become an indispensable tool to monitor calcium dynamics during physiological responses, and they are widely used as a proxy to monitor activity in neu...

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Detalles Bibliográficos
Autores principales: Singh, Mahendra, Lujan, Brendan, Renden, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186185/
https://www.ncbi.nlm.nih.gov/pubmed/29935099
http://dx.doi.org/10.1002/syn.22040