Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages

BACKGROUND: SAM domain and HD domain containing protein 1 (SAMHD1) is a host anti-HIV-1 restriction factor known to suppress viral reverse transcription in nondividing myeloid cells by its dNTP triphosphorylase activity that depletes cellular dNTPs. However, HIV-2 and some SIV strains rapidly replic...

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Detalles Bibliográficos
Autores principales: Mahboubi, Bijan, Gavegnano, Christina, Kim, Dong-Hyun, Schinazi, Raymond F., Kim, Baek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186296/
https://www.ncbi.nlm.nih.gov/pubmed/30316304
http://dx.doi.org/10.1186/s12977-018-0452-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186296/
https://www.ncbi.nlm.nih.gov/pubmed/30316304
http://dx.doi.org/10.1186/s12977-018-0452-z

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