Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by Enhancing Parasitism, Inflammation, and Reactive Tissue Damage in Trypanosoma cruzi-Infected Mice

Suramin (Sur) acts as an ecto-NTPDase inhibitor in Trypanosoma cruzi and a P2-purinoceptor antagonist in mammalian cells. Although the potent antitrypanosomal effect of Sur has been shown in vitro, limited evidence in vivo suggests that this drug can be dangerous to T. cruzi-infected hosts. Therefor...

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Detalles Bibliográficos
Autores principales: Novaes, Rômulo D., Santos, Eliziária C., Cupertino, Marli C., Bastos, Daniel S. S., Mendonça, Andréa A. S., Marques-da-Silva, Eduardo de Almeida, Cardoso, Sílvia A., Fietto, Juliana L. R., Oliveira, Leandro L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186315/
https://www.ncbi.nlm.nih.gov/pubmed/30364017
http://dx.doi.org/10.1155/2018/7385639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186315/
https://www.ncbi.nlm.nih.gov/pubmed/30364017
http://dx.doi.org/10.1155/2018/7385639

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