Activation of PAR4 Upregulates p16 through Inhibition of DNMT1 and HDAC2 Expression via MAPK Signals in Esophageal Squamous Cell Carcinoma Cells

A previous study showed that a downexpression of protease-activated receptor 4 (PAR4) is associated with the development of esophageal squamous cell carcinoma (ESCC). In this study, we explored the relationship between PAR4 activation and the expression of p16, and elucidated the underlying mechanis...

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Detalles Bibliográficos
Autores principales: Wang, Ming, An, Shuhong, Wang, Diyi, Ji, Haizhen, Guo, Xingjing, Wang, Zhaojin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186345/
https://www.ncbi.nlm.nih.gov/pubmed/30363984
http://dx.doi.org/10.1155/2018/4735752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186345/
https://www.ncbi.nlm.nih.gov/pubmed/30363984
http://dx.doi.org/10.1155/2018/4735752

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