Destabilizing Domains Enable Long-Term and Inert Regulation of GDNF Expression in the Brain

Regulation of therapeutic transgene expression can increase the safety of gene therapy interventions, especially when targeting critical organs such as the brain. Although several gene expression systems have been described, none of the current systems has the required safety profile for clinical ap...

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Detalles Bibliográficos
Autores principales: Quintino, Luis, Namislo, Angrit, Davidsson, Marcus, Breger, Ludivine S., Kavanagh, Patrick, Avallone, Martino, Elgstrand-Wettergren, Erika, Isaksson, Christina, Lundberg, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187056/
https://www.ncbi.nlm.nih.gov/pubmed/30324128
http://dx.doi.org/10.1016/j.omtm.2018.08.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187056/
https://www.ncbi.nlm.nih.gov/pubmed/30324128
http://dx.doi.org/10.1016/j.omtm.2018.08.008

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