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Destabilizing Domains Enable Long-Term and Inert Regulation of GDNF Expression in the Brain
Regulation of therapeutic transgene expression can increase the safety of gene therapy interventions, especially when targeting critical organs such as the brain. Although several gene expression systems have been described, none of the current systems has the required safety profile for clinical ap...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187056/ https://www.ncbi.nlm.nih.gov/pubmed/30324128 http://dx.doi.org/10.1016/j.omtm.2018.08.008 |